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  汤耀辉

  长聘副教授，博士生导师，科技部国家重点研发计划首席青年科学家，2019年度中国卒中学会优秀科技工作者，2021年度上海市青年科技启明星（A类），2023年度上海市东方英才。于2014年获得必赢565net官网博士学位。2014-2018年先后在德国马克思普朗克研究所、美国斯坦福大学从事博士后研究。2018年3月担任必赢565net官网长聘教轨助理教授，同时担任Aging&Disease杂志副主编，Stroke and Vascular Neurology的Assistant Editor以及多本SCI杂志编委；担任 中国卒中协会脑血流与代谢分会委员、上海市衰老与退行性疾病学会血管衰老与心脏血管疾病分会委员和上海市实验动物学会教育培训和科普专业委员会，长期从事神经生物学和神经病学，特别是脑血管疾病的转化医学研究。目前主持国家重点研发计划“干细胞与转化研究”青年项目、国家自然科学基金、必赢565net官网医工交叉重点基金等，在Nature Communications, Advanced Science, Nano Today, Advanced functional materials, Stroke，Journal of cerebral blood flow and metabolism，Stem Cell Reports等国际重要期刊上共发表SCI论文60余篇，总影响因子500余分，H-因子33，引用3700余次。 

  
  

2005.9-2009.7   北京林业大学               学士

2009.9-2014.7   必赢565net官网               博士

2014-2018年先后在德国马克思普朗克研究所、美国斯坦福大学从事博士后研究。现任必赢565net官网长聘副教授，同时担任多本SCI杂志编委（Frontiers in cellular Neuroscience, Current stem cell research and therapy, ARC journal of neuroscience, Sciencematters等）；长期从事神经生物学和神经病学，特别是脑血管疾病的转化医学研究。

2014.7-2015.9   德国马克斯普朗克研究所     博士后

      2015.10-2018.2  美国斯坦福大学                  博士后

      2018.3-2022.6    必赢565net官网                     长聘教轨助理教授

      2022.6-2023.12  必赢565net官网                     长聘教轨副教授

      2024.1-至今        必赢565net官网                    长聘副教授

脑血管病的发病机制；胶质细胞在脑血管病中的作用；干细胞和外泌体治疗缺血性脑卒中；组织工程

主持基金项目：

1.  国家自然科学基金面上项目，2024/01-2027/12

2. 必赢565net官网医工交叉重点基金，2023/01-2025/12

3. 上海市“科技创新行动计划”启明星项目（A类）, 2021/07-2024/06

4.  国家自然科学基金面上项目，2021/01-2024/12

5. 国家重点研发计划重点专项青年项目, 2019/09-2024/12

6. 国家自然科学基金青年项目，2019/01-2021/12

7. 必赢565net官网医工交叉重点基金，2019/01-2021/12

8. 必赢565net官网医工交叉青年基金A，2019/01-2021/12

9. 必赢565net官网医工交叉青年基金B，2019/01-2021/12

参与基金项目：

1. 上海市教育委员会科研创新计划项目，2019/01-2023/12

2. 国自然重点，2020/01-2024/12

1. Xiaojing Shi#, Longlong Luo#, Jixian Wang#, Hui Shen, Yongfang Li, Muyassar Mamtilahun, Chang Liu, Rubing Shi, Joon Hyuk Lee, Hengli Tian, Zhijun Zhang, Yongting Wang, Won-Suk Chung*, Yaohui Tang*, and Guo-Yuan Yang*. (Co-corresponding author) Stroke subtype-dependent synapse elimination by reactive gliosis in mice. Nature Communications. 2021. Accepted. (IF:17.694)

2.  Fengzhen Cui, Qingfei Pan, Siyi Wang, Faming Zhao, Runxin Wang, Tingting Zhang, Yaying Song, Jun He, Haolin Zhang, Qiang Weng, Yang Jin, Wei Xia, Yuanyuan Li, Guo-Yuan Yang, Winnok De Vos, Jean-Pierre Timmermans, Shunqing Xu*, Yaohui Tang* and Xia Sheng*. (Co-corresponding author) Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring. Advanced Science, 2021: e2102686. (IF: 17.521) 

3.  Cheng Wang#, Xuewei Yang#, Yixu Jiang, Lin Qi, Deli Zhuge, Tongtong Xu, Yiyan Guo, Mingwu Deng, Wenjie Zhang, Dongyan Tian, Qingqing Yin, Li Li, Zhijun Zhang, Yongting Wang, Guo-yuan Yang, Yijie Chen*, Yaohui Tang*.  (Co-corresponding author) Targeted Delivery of Fat Extract by Platelet Membrane-Cloaked Nanocarriers for the Treatment of Ischemic Stroke. Journal of Nanobiotechnology. 2022 May 31;20(1):249. (IF:10.435)

4. Huitong Ruan#, Yongfang Li#, Cheng Wang, Yixu Jiang, Yulong Han, Yiwei Li, Dandan Zheng, Jing Ye, Gang Chen, Guo-yuan Yang, Lianfu Deng, Ming Guo, Xingcai Zhang*, Yaohui Tang*, Wenguo Cui*.  (Co-corresponding author)  Click Chemistry Extracellular Vesicle /Peptide/Chemokine Nanomissiles for Treating CNS Injuries. Acta Pharmaceutica Sinica B. 2022, Accepted. (IF:14.903)

5. Qi Zhang#, Chang Liu#, Rubing Shi, Shiyi Zhou, Huimin Shan, Lidong Deng, Tingting Chen, Yiyan Guo, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang*, Yaohui Tang*. (Co-corresponding author) Blocking C3d +/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke. Aging and disease. (IF:9.968)

6. Ming Ma, Yimeng Shua, Yaohui Tang* and Hangrong Chen*.  (Co-corresponding 

author) Multifaceted application of nanoparticle-based labeling strategies for stem cell 

therapy. Nano Today 34, 100897. (IF:20.722)

7. Minghua Yao, Xiaojing Shi, Changjing Zuo, Ming Ma*, Lu Zhang, Hongbo Zhang, Xin Li,

Guo-Yuan Yang, Yaohui Tang*, Rong Wu*. (Co-corresponding author) Engineering of 

SPECT/Photoacoustic Imaging/Antioxidative Stress Triple-Function Nanoprobe for Advanced 

Mesenchymal Stem Cell Therapy of Cerebral Ischemia. ACS Appl Mater Interfaces. 2020 Aug 

26;12(34):37885-37895. (IF:10.383)

8. Yaohui Tang, Xinming Tong, Bogdan Conrad and Fan Yang. Injectable and in situ 

Crosslinkable Gelatin Microribbon Hydrogels for Stem Cell Delivery and Bone Regeneration in 

vivo. Theranostics 2020; 10(13): 6035–6047. (IF: 11.6)

9. Pengju Zhang*, You Li*, Yaohui Tang*, Hui Shen, Jiankai Li, Zhengfang Yi, Qinfei Ke and He Xu. (Co-first author) Copper-Based Metal-Organic Framework as A Controllable Nitric Oxide-Releasing Vehicle for Enhanced Diabetic Wound Healing. ACS Applied Materials & Interfaces. 2020 Apr 22;12(16):18319-18331. (IF:10.383)

10. Hui-Min Shan, Minhua Zang, Qi Zhang, Ru-Bing Shi, Xiao-Jing Shi, Muyassar Mamtilahun, Chang Liu, Long-long Luo, Xiaoying Tian, Zhijun Zhang, Guo-Yuan Yang, Yaohui Tang*, Jun Pu*, Yongting Wang*. (Co-corresponding author) Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice. J Neuroinflammation. 2020; 17: 164. (IF:9.587)

11. Yaying Song, Zongwei Li, Tingting He, Meijie Qu, Lu Jiang, Wanlu Li, Xiaojing Shi, Jiaji Pan, Linyuan Zhang, Yongting Wang, Zhijun Zhang*, Yaohui Tang*  and Guo-Yuan Yang*.  (Co-corresponding author) M2 microglia-derived exosomes protect the mousebrain from ischemia-reperfusion injury via exosomalmiR-124. Theranostics. 2019; 9(10):2910-2923. (IF:11.6)

12. Meijie Qu, Jiaji Pan, Liping Wang, Panting Zhou, Yaying Song, Shuhong Wang, Lu Jiang, JieliGeng, Zhijun Zhang, Yongting Wang, Yaohui Tang* and Guo-Yuan Yang*. (Co-corresponding author) MicroRNA-126 regulates angiogenesis and neurogenesis in a mouse model of focal cerebral ischemia. Molecular Therapy-Nucleic Acid. 2019 Feb 11;16:15-25. (IF:10.183)

13. Yaohui Tang,Chunfu Zhang, Jixian Wang, Xiaojie Lin, Lu Zhang, Yi Yang, Yongting Wang, Zhijun Zhang, Jeff W.M. Bulte, Guo-Yuan Yang. MRI/SPECT/Fluorescent tri-Modal probe for evaluating the homing and therapeutic efficacy of transplanted mesenchymal stem cells in a rat ischemic stroke model. 2015. Advanced Functional Materials. Feb; 25(7):1024-34 (IF：19.924) 

生物学导论，32学时，本科生

神经生物学实验基础，32学时，研究生

学术报告会，32学时，研究生

2023-至今       Aging and disease                                                    副主编

2022.7-至今      Stroke and Vascular Neurology                                 Assistant Editor

2016.7 -  至今    Frontiers in cellular neuroscience                                  编委

2019.11- 至今    Current Stem Cell Research & Therapy                          编委

2019.6 -  至今    中国卒中协会脑血流与代谢分会                                   委员

2019.10- 至今    上海市实验动物学会教育培训和科普专业委员会             委员

2019. Stroke conference, Early Career Investigator Award

Brain 2019 Young Investigator award

2019年度中国卒中学会优秀科技工作者

2020 上海市青年科技启明星（A类）

2023年度上海市东方英才（青年项目）