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  饶汉钰

  助理研究员。2021年9月毕业于必赢565net官网，获理学博士学位，同年就职于必赢565net官网，主要从事肿瘤相关基因在肿瘤中的机制研究和间充质干细胞载体细胞免疫治疗研究。近年来在肿瘤领域主流SCI期刊上发表论文数篇，已授权中国发明专利1项。参与必赢565net官网-悉尼大学合作研究项目，曾于2019年赴澳大利亚悉尼大学必赢565net官网访学。主持国家自然科学基金青年科学基金项目1项，先后参与国家自然科学基金重点项目与面上项目、上海市科委等6项科研项目。

(1) 肿瘤相关基因在肿瘤发病中的功能机制
(2) 间充质干细胞载体细胞免疫治疗

1. Rao H, Liu C, Wang A, Ma C, Xu Y, Ye T, Su W, Zhou P, Gao WQ, Li L, Ding X. SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer. Nat Commun. 2023 Nov 21;14(1):7572.

2. Rao H, Li X, Liu M, Liu J, Feng W, Tang H, Xu J, Gao WQ, Li L. Multilevel Regulation of β-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma. Cancer Res. 2021 Jul 1;81(13):3554-3567.

3. Rao H, Li X, Liu M, Liu J, Li X, Xu J, Li L, Gao WQ. DIRAS2 promotes renal cell carcinoma formation by activating the mitogen-activated protein kinase pathway in the absence of von Hippel-Lindau protein. Oncogene. 2020 May;39(19):3853-3866.

4. Feng W, Ma C, Rao H, Zhang W, Liu C, Xu Y, Aji R, Wang Z, Xu J, Gao WQ, Li L. Setd2 deficiency promotes gastric tumorigenesis through inhibiting the SIRT1/FOXO pathway. Cancer Lett. 2023 Nov 28;579:216470.

5. Liu C, Ni L, Li X, Rao H, Feng W, Zhu Y, Zhang W, Ma C, Xu Y, Gui L, Wang Z, Aji R, Xu J, Gao WQ, Li L. SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signalling pathway in the absence of VHL. Clin Transl Med. 2023 Nov;13(11):e1468.

6. Ma C, Liu M, Feng W, Rao H, Zhang W, Liu C, Xu Y, Wang Z, Teng Y, Yang X, Ni L, Xu J, Gao WQ, Lu B, Li L. Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway. Clin Transl Med. 2023 Nov;13(11):e1475.

7. Liu M, Rao H, Liu J, Li X, Feng W, Gui L, Tang H, Xu J, Gao WQ, Li L. The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis. Redox Biol. 2021 Jul;43:102004.

9. Liu J, Feng W, Liu M, Rao H, Li X, Teng Y, Yang X, Xu J, Gao W, Li L. Stomach-specific c-Myc overexpression drives gastric adenoma in mice via AKT/mTOR signaling. Bosn J Basic Med Sci. 2020 Nov 19.